Frameshifting: Another Epic Modified mRNA Scandal

Frameshifting FI
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Ribosomal frameshifting is the latest shameful disclosure in the long list of outrageously bungled science relating to the modified RNA products. Investigational studies are fountaining proof of contamination, batch variability, immune system distortion, integration into recipient’s DNA, and cancer causation. Of course these studies ought to have been performed by the manufacturers, and published, before this novel platform was unleashed, and the latest shoes to drop include yet another mechanism for blood clotting (a useful summary here) and frameshifting. 

What is frameshifting and why is it a problem?

How Do mRNA Products Work?

Described well by Doctors for Covid Ethics in their free online publication, mRNA Vaccine Toxicity, the Pfizer and Moderna products consist of a modified, synthetic messenger ribonucleic acid (mRNA).  Naturally occurring mRNA contains genetic instructions consisting of four structural subunits, called nucleosides, required for the synthesis of all proteins.  These are demonstrated in the graphic below.

Frameshifting nucleosides
Image captured for criticism/review and reporting current events under Fair Dealing – The Copyright Act 1994

Vaccine mRNA is wrapped inside a synthetic lipid envelope or lipid nanoparticle (LNP). This serves two main functions: to protect the fragile mRNA and to facilitate its uptake into the host cell, where ribosomes ‘read’ the genetic instruction to synthesise the spike protein.

LNPs can be taken up by any cell, but Pfizer studies showed they accumulate at especially high amounts in the liver, spleen and ovaries. Once inside the cell, the synthetic mRNA sheds its lipid layer and attaches to the cellular ribosomes. These protein factories then translate the genetic code to build a string of spike-specific amino acids (the building blocks of proteins). These grow into long chains and then fold into spike proteins.

The spike protein is then transported to the surface of the host cell, where the immune system recognises it as a foreign protein and develops specific antibodies which attach to it. This illustration from the Nobel Prize website provides a simplified depiction of the process.  The immune system may try to attack cells displaying the spike protein on their surface as they appear to be virally infected.

Frameshifting mRNA to protein synthesis Nobel
Image captured for criticism/review and reporting current events under Fair Dealing – The Copyright Act 1994

One of the naturally occurring nucleosides of mRNA is uracil, which binds to a sugar (ribose) and phosphate, to become uridine. This forms part of the genetic code in naturally occurring mRNA.

The Nobel Prize in Physiology or Medicine was awarded in 2023 to two scientists, Katalin Karikó and Drew Weissman, for their discovery that artificial modification of the naturally-occurring uridine helps it to evade the normal recognition and destruction by the immune system as it travels to the host cells. Foreign mRNA is usually destroyed and removed very quickly.  This artificial modification replaces the naturally occurring uridine in mRNA, with a specific methylated pseudouridine, named N1-methylpseudouridine, abbreviated to m1ψ.  This modification increases the amount and duration of spike protein produced by the host cells.

What is Frameshifting?

Ribosomes read the genetic code of mRNA in “frames” of three genetic codes per amino acid. Should the ribosome move its reading by one nucleoside either forward or backward, then the reading will occur out of frame.  This causes a distinctively different code reading, known as frameshifting. When this occurs accidentally, aberrant proteins can be synthesised.  As in computer programming, corrupted code can cause a real mess.

Why Is Frameshifting in mRNA Vaccines a Problem?

Part of the immune evasion action of m1ψ involves delaying the translation of ribosomes into spike protein, which can unintentionally induce frameshifting. According to researchers Mulroney et al in N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting, m1ψ increases ribosomal frameshifting during mRNA translation leading to the synthesis of entirely different, random and potentially damaging proteins, about 8% of the time. Imagine a scratched record that jumped that much! Where translation of mRNA to spike protein is intended, but frameshifting results in synthesis of an aberrant protein, mutant or ‘garbage’ proteins can be produced.

Mulroney et al claim that “there are no adverse outcomes reported from mistranslation of mRNA-based SARS-CoV-2 vaccines in humans“. To the contrary, synthesis of mutant proteins does cause unintended immune system responses resulting in a range of auto-immune diseases. These include demyelinating conditions such as multiple sclerosis.

In her thorough analyses of the Vaccine Adverse Event Reporting System (VAERS), Dr Jessica Rose has identified very strong safety signals for increased rates of autoimmune disorders and multiple sclerosis following COVID-19 mRNA injections administered between 2021 and 2023, compared with historical rates following influenza vaccines.

Frameshifting VAERS Jessica Rose
Image captured for criticism/review and reporting current events under Fair Dealing – The Copyright Act 1994

Since we’re focusing on the nervous system, even more worrying is prion disease. Prions are tiny ‘nonsense’ protein fragments that cause chaos around them, and a domino effect where adjacent normal proteins start to misfold and lose their usual function, causing serious symptoms. Bovine Spongiform Encephalitis (BSE, or “Mad Cow Disease”) is one example, and another is Huntington’s chorea, which is genetically determined. The synthetic spike protein, that the body was tricked into making by the code in the vaccine mRNA, is another.

Seneff and Nigh warned of the possibility of serious prion side effects in 2021, which they updated in 2023.  Another Nobel Prize winner, Dr Luc Montagnier, published a tragic case series of rapid onset fatal dementias closely following administration of covid mRNA (Pfizer, Moderna) and DNA adenovector (Astra-Zeneca) injections.

What Else is Wrong With This Story?

It is interesting to note that in their scientific background to the discovery of m1ψ mRNA modification, Nobel falsely state that “In today’s globally interconnected society the risk of new pandemics is greater than ever before. Pandemics are usually caused by zoonotic viruses that cross the species barrier into humans and spread through droplet- or aerosol-mediated transmission, causing airway infections.

Actually, modern living standards have reduced the risk of pandemics occurring, due to our knowledge of health protection measures, access to clean water and sanitation, and to effective treatments.  As we are discovering,  dramatic risk to human health can come from pandemic microbes subject to gain of function research, which receives enormous amounts of funding, and is deeply connected to the military industrial complex which has commandeered the pharmaceutical industry into their biowarfare activities.

As already observed with the Royal Society and other previously prestigious institutions, it is apparent that Nobel have also been captured by an ideological power structure involved in the destruction of science, medicine and societal health.

We never tire of sharing Dr David Bell’s infographic of this ideology. This serves as a reminder of what corrupted power structures such as the United Nations and their various subsidiaries (eg World Health Organization, World Bank) and partners (eg World Economic Forum, CEPI, GAVI) are attempting to impose on humanity.

Frameshifting Pandemic Ideology
Image captured for criticism/review and reporting current events under Fair Dealing – The Copyright Act 1994

To learn more about these plans which threaten human rights, dignity and health, see Dr Meryl Nass’ November 2023 article, Why is Everyone Concerned About the WHO? If you share these concerns, do what you can to alert family, friends, colleagues and neighbours. Contact your MP and find out what they are doing to stop New Zealand’s involvement in this global governance system. Educate them on GM humans and frameshifting too.

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